Using mixed-omics to understand multimorbidities in polygenic disorders

Project Code: 10357691

Faculty: Liggins Institute

Department: Liggins Institute

Main Supervisor: Dr Justin O'Sullivan

Application open date: 01 Nov 2019

Application deadline: 30 Nov 2020

Introduction

Two PhD positions are available to use mixed omics, genetic variation, and electronic records to study multimorbidity in polygenic non-communicable diseases with Dr Justin M. O’Sullivan (https://www.researchgate.net/profile/Justin_OSullivan2). This project will be undertaken at the Liggins Institute, the University of Auckland, New Zealand.

 

How a particular genotype defines a phenotype and cellular responses to environmental cues is central to understanding cell development and the continuing evolution of personalized medicine. However, frameworks for understanding the possible mechanisms that link the genotype and phenotype are limited by our current concept(s) of genes and gene regulation. In our group, we are attempting to understand genetic variation within the context of the spatial and temporal organization of the mammalian genome. This approach is providing novel insights into different phenotypes .

 

Proximity-ligation (e.g.HiC) captures the structure of the genome and the underlying genome biology. You will work to decode the genome biology by integrating multi omic data and electronic health records. 

These projects will be supervised by Dr. Justin M. O’Sullivan. They will use computational techniques to integrate new and existing spatial and epigenetic data to understand the link between genotype and phenotype in mammalian cells.

 

Applicants should have a background in bioinformatics and biology, or related subjects.

 

The Liggins institute focuses on early life development and research across the life course (The Lancet (2015) 386: 234).

 

Requests for further information and applications for positions should be sent to justin.osullivan@auckland.ac.nz. Applications should include a full CV, an academic transcript, and a cover letter outlining your interests in relation to our research. Applications will be reviewed as as they are received with an aim of the positions starting in early 2020.

 

 

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