Project Code: 10381712
Faculty: Liggins Institute
Department: Liggins Institute
Main Supervisor: Dr Justin O'Sullivan
Principal investigator: Professor Melissa Wake (mwak005)
Application open date: 06 Jun 2017
Application deadline: 15 Dec 2017
Enrolment information: NZ Citizens, NZ Permanent Residents, International
The cumulative role of genetic variants on parameters of obesity phenotypes (e.g. BMI, adiposity, lipid profile and growth) has not been fully explored, particularly across different stages of the life course (childhood to adulthood).
This project is available to students able to attract funding stipends, e.g. via university or international scholarships.
**Please include undergraduate and any postgraduate transcripts with your application.**
Aim: This PhD will dissect the role of genetic variation in shaping growth and anthropometry.
Description: We are generating a unique multigenerational set of genotypic data from over 1500 parents and their children as part of the Growing Up in Australia study with which to dissect the genetic architecture of obesity-related phenotypes in both generations. This will be done using a four-dimensional network analysis approach (developed at the Liggins Institute, University of Auckland) to the unique biospecimens and paired cross-generational phenotypic data of Growing Up in Australia’s Child Health CheckPoint study. This network approach will maximise the utility of genomic data to predict risk and effective targeting of interventions to reduce obesity-related disease in children and adults, thereby providing opportunities to shape our social, health, and therapeutic strategies.
The PhD candidate will be contributing to the data derivation and management of the relevant CheckPoint and LSAC datasets, in collaboration with the study team, and conducting quantitative analyses of the study data to address the study objectives.
This project can be undertaken by a student based at the Liggins Institute (University of Auckland, New Zealand) or the Murdoch Children’s Research Institute (University of Melbourne, Australia).
- The current research of Dr Justin O'Sullivan
- Computational biology and biophysics PhD Positions at the Liggins Institute
- Decoding SNPs in context
- The effect of nutritional strategies on establishment of the gut microbiome
- The placental transcriptome in severe early onset fetal growth restriction: the effect of sildenafil citrate.