Inflammation induced by Topical Eye Drops on the Trabecular Meshwork in Glaucoma

Project Code: 10478091

Faculty: Faculty of Medical and Health Sciences

Department: Ophthalmology

Main Supervisor: Professor Helen Danesh-Meyer

Application open date: 23 Jul 2021

Application deadline:

Enrolment information: NZ Citizens, NZ Permanent Residents, International

Introduction

Topical eye drops are the mainstay of glaucoma therapy. However, eye drops are comprised of both an active ingredient and a preservative. This project will investigate the role of  inflammation and the inflammasome pathway induced by topical medications. It will involve in vitro analysis of trabecular meshwork cell lines. 

What we are looking for in a successful applicant

The successful applicant should have laboratory experience in managing cell lines in vivo,  ELISA, immunohistochemistry, use of confocal microscopy.

Objective

To undertake in vitro investigations on trabecular meshwork cells to evaluate if treatments presently used for glaucoma, or the preservatives they are combined with cause inflammation and damage to trabecular cells.

Other information