Project Code: 5531
Main Supervisor: Avan Suinesiaputra
Application open date: 30 Apr 2015
Model-based LV dyssynchrony assessment
Cardiac resynchronisation therapy (CRT) can dramatically improve the morbidity and mortality of patients with heart failure, however 30% of patients who undergo CRT do not receive any benefit. The high percentage of non-responders is due to the lack of appropriate selection criteria. This requires accurate assessment of the type of mechanical dyssynchrony, as well as the etiology of the disease including scar burden and location. The weak point is currently the assessment of left ventricular dyssynchrony (LVD), where current methods such as echocardiography have been shown to be non-predictive. The aim of this research is to develop a novel LVD assessment method derived from cardiac MR (CMR) images.
Funding agent: Auckland Medical Research Foundation
Right ventricular function in adult congenital heart disease
Children with congenital heart disease have improved mortality due to better interventions early in life. However, heart failure is a significant problem in adulthood. Accurate measurement of right heart function is an important guide to treatment of these patients. This project aims to develop an interactive three- dimensional time-varying analysis procedure which takes direct advantage of MRI multiplanar data to provide a fast and accurate evaluation of right ventricular function. This will result in a widely applicable clinical tool which will reduce the need for invasive procedures, thereby reducing patient risks and reducing healthcare expenditure.
Funding agent: National Heart Foundation
Cardiac Atlas Project
The Cardiac Atlas Project (CAP) is an NIH funded, international, multi-institutional project, with over 3000 cardiac MRI studies and clinical data stored in the database. CAP is led by the University of Auckland, New Zealand. CAP researchers have developed software tools for the visualization and analysis of cardiac MRI data and for the generation of 4D mathematical models from these data. Currently, CAP is being expanded into patients with congenital heat disease as a collaboration with the University of California, San Diego.
Funding agents: Faculty Research Development Fund, National Institutes of Health USA